The following is a list of frequently requested telephone numbers. If you can't find what you are looking for, please call Poplar Bluff Regional Medical Center's main switchboard at (573) 785-7721. For patient names and room numbers, please contact the main switchboard for further assistance.
| Department | Phone Number |
| Administration | (573) 686-5311 |
| Admitting | (573) 727-2660 |
| Business Office | (573) 727-2721 |
| Cancer Treatment Center | (573) 686-5300 |
| Cardiovascular Services | (573) 785-0080 |
| Emergency Department | (573) 776-9290 |
| Employment Opportunities Job Line | (573) 727-2500 |
| Gift Shop - North Campus | (573) 686-5966 |
| Marketing | (573) 727-2762 |
| Nursing Administration | (573) 686-5342 |
| P.A.R.C. (Physical Assessment & Rehabilitation Center) | (573) 686-5985 |
| Pain Management Center | (573) 686-8154 |
| RehabCare Center | (573) 727-2360 |
| Volunteer Services | (573) 727-2764 |
| Women's Health Center | (573) 727-2140 |
| Wound Healing & Hyperbaric Center | (573) 686-8199 |
