Drug ReferencesAluminum Hydroxide
Aluminum Hydroxide; Magnesium Carbonate
Diseases and ConditionsBarrett's Esophagus
Stomach and Duodenal Ulcers (Peptic Ulcers)
An ulcer is an open sore, or lesion, usually found on the skin or mucous membrane areas of the body.
An ulcer in the lining of the stomach or duodenum, where hydrochloric acid and pepsin are present, is referred to as a peptic ulcer.
When the ulcer is in the stomach, it is called a gastric ulcer.
When the ulcer is in the duodenum, it is called a duodenal ulcer.
In the past, it was believed lifestyle factors, such as stress and diet caused ulcers. Later, researchers determined that stomach acids--hydrochloric acid and pepsin--contributed to ulcer formation.
Today, research shows that most ulcers develop as a result of infection with a bacterium called Helicobacter pylori (H. pylori).
It is believed that, although all of these factors--lifestyle, acid and pepsin, and H. pylori--play a role in ulcer development, H. pylori is considered to be the primary cause in most cases.
Factors suspected of playing a role in the development of stomach or duodenal ulcers include:
Helicobacter pylori. Research shows that most ulcers develop as a result of infection with a bacterium called Helicobacter pylori (H. pylori). The bacterium produces substances that weaken the stomach's protective mucus and make it more susceptible to the damaging effects of acid and pepsin.
Smoking. Studies show smoking increases the chances of getting an ulcer, slows the healing process of existing ulcers, and contributes to ulcer recurrence. This is yet another health-related reason for children and teenagers who smoke to quit.
Caffeine. Caffeine seems to stimulate acid secretion in the stomach, which can aggravate the pain of an existing ulcer. However, the stimulation of stomach acid cannot be attributed solely to caffeine.
Stress. Although emotional stress is no longer thought to be a cause of ulcers, people with ulcers often report that emotional stress increases ulcer pain. Physical stress, however, may increase the risk of developing ulcers, particularly in the stomach. For example, people with injuries (such as severe burns) and people undergoing major surgery often require rigorous treatment to prevent ulcers and ulcer complications.
Acid and pepsin. It is believed that the stomach's inability to defend itself against the powerful digestive fluids, hydrochloric acid and pepsin, contributes to ulcer formation.
Nonsteroidal anti-inflammatory drugs (NSAIDs). These drugs (such as aspirin, ibuprofen, and naproxen sodium) make the stomach vulnerable to the harmful effects of acid and pepsin. They are present in many nonprescription medications used to treat fever, headaches, and minor aches and pains.
The following are the most common symptoms for ulcers. However, each individual may experience symptoms differently.
Although ulcers do not always cause symptoms, the most common ulcer symptom is a gnawing or burning pain in the abdomen between the breastbone and the navel. The pain often occurs between meals and in the early hours of the morning. It may last from a few minutes to a few hours. Less common ulcer symptoms include:
Nausea and vomiting
Loss of weight
Feeling tired and weak
The symptoms of stomach and duodenal ulcers may resemble other digestive conditions or medical problems. Consult your child's doctor for a diagnosis.
Without proper treatment, people with ulcers may experience serious complications. The most common problems include:
Bleeding. As the lining of the stomach or duodenal wall is eroded, blood vessels may also be damaged, causing bleeding.
Perforation. Sometimes a hole has worn through the wall of the stomach or duodenum, and bacteria and partially digested food can spill through the opening into the sterile abdominal cavity (peritoneum) and cause peritonitis, an inflammation of the abdominal cavity and wall.
Narrowing and obstruction. Ulcers located at the end of the stomach (where the duodenum is attached) can cause swelling and scarring, which can narrow or close the intestinal opening. This obstruction can prevent food from leaving the stomach and entering the small intestine, resulting in vomiting the contents of the stomach.
Because treatment protocols may be different for different types of ulcers, it is important to adequately diagnose ulcer disease and H. pylori before starting treatment. For example, for an NSAID-induced ulcer, treatment is quite different from the treatment for a person diagnosed with an ulcer caused by the bacterium, H. pylori.
In addition to a complete medical history and physical examination, diagnostic procedures for ulcers may include:
Upper GI (gastrointestinal) series. An examination of the esophagus, stomach, and duodenum (the first section of the small intestine). Your child will drink a fluid called barium. Barium is a chalky liquid used to coat the inside of organs so that they will show up on an X-ray. X-rays are then taken to look at your child's upper digestive tract.
Endoscopy. A test that uses a small, flexible tube with a light and a camera lens at the end (endoscope) to examine the inside of part of the digestive tract. Tissue samples from inside the digestive tract may also be taken for examination and testing.
Blood, stool, breath, and stomach tissue tests. Performed to detect the presence of H. pylori. Although some of the tests for H. pylori may occasionally give false-positive or false-negative results, research shows that these tests can still be accurate in detecting the bacteria.
Specific treatment will be determined by your child's doctor based on the following:
Your child's age, overall health, and medical history
The extent of the disease
Your child's tolerance for specific medications, procedures, or therapies
The expectations for the course of the disease
Your opinion or preference
Recommended treatment may include:
Lifestyle changes. In the past, doctors advised people with ulcers to avoid spicy, fatty, or acidic foods. However, a bland diet is now known to be ineffective for treating or avoiding ulcers. No particular diet is helpful for most ulcer patients. If it seems that certain foods cause irritation, please discuss the problem with your child's doctor.
Some children and teenagers smoke, with or without their parent's knowledge or permission. Smoking has been shown to delay ulcer healing and has been linked to ulcer recurrence.
Medications. Doctors may treat stomach and duodenal ulcers with several types of medications, including the following:
Antibiotics. Used to kill the bacteria.
H2-blockers. Reduce the amount of acid the stomach produces by blocking histamine, a powerful stimulant of acid secretion.
Proton pump inhibitors. More completely block stomach acid production by stopping the stomach's acid pump--the final step of acid secretion.
Mucosal protective agents. Shield the stomach's mucous lining from the damage of acid, but do not inhibit the release of acid.
When treating H. pylori, these medications or procedures are often used in combination.
Surgery. In most cases, anti-ulcer medicines heal ulcers quickly and effectively, and eradication of H. pylori prevents most ulcers from recurring. However, rarely people do not respond to medication and may require surgery.